Of 110 potentially gout-associated polymorphic loci, 3 (MUC1, THBS3, and TRIM46), 3 (CLNK, SLC2A9, and WDR1), 5 (ABCG2, DMP1, MEPE, PKD2, and SPP1), 4 (PRSS16, ZSCAN31, CARMIL1, and H4C5), 8 (CDC42BPG, MAP3K11, NRXN2, OVOL1, RPS6KA4, SLC22A11, CNIH2, and POLD3), 4 (SLC38A1, VDR, INHBC, and R3HDM2), and 5 (CUX2, ACAD10, ALDH2, NAA25, and TRAFD1) genes were located on the human 1q22, 4p16.1, 6p21.1-p21.2, 11q13.1-q13.2, 12q13.11-q13.3, and 12q24.1 chromosome segments, respectively. Here, RPS6KA4 is linked to gout.