In addition, a recent large genome-wide association (GWA) meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) that was conducted to identify new risk loci for LOAD also revealed that the pathway analysis implicates lipid metabolism and APP metabolism, showing that genetic variants affecting APP and Aβ processing are associated not only with early-onset autosomal dominant Alzheimer’s disease (EOAD) but also with LOAD (Kunkle et al., 2019). Here, APP is linked to Alzheimer disease.