Thus, to assess the prophylactic hepatoprotective and anti-HCC effects of LPE, three functional hallmarks of the liver, namely, metabolic, biosynthetic, and detoxification were monitored using endpoints such as survival rate, body weight changes, gross liver anatomy, liver histology, biochemical parameters (α-fetoprotein, C-reactive protein, albumin, total protein, prothrombin time, AST, ALT, ALP, GGT, and bilirubin), and hematological assessments. This evidence concerns the gene F2 and hepatocellular carcinoma.