First, TYG can reflect lipid metabolism, and the survival advantage of high TYG might be partly attributed to the downregulation of certain oncogenes and/or upregulation of PD‐1 expression, as determined by the immunosuppressive effect of obesity, ultimately leading to greater susceptibility to PD‐1 inhibitors.22 Here, PDCD1 is linked to obesity due to melanocortin 4 receptor deficiency.