GO enrichment analysis revealed that the 155 targets were primarily associated with response to peptide, membrane microdomain, and protein serine/threonine/tyrosine kinase activity, etc. KEGG pathway enrichment analysis showed that several signaling pathways, such as the PI3K-Akt signaling pathway, MAPK signaling pathway, and AGE-RAGE signaling pathway in diabetic complications, were implicated in the anti-T2DM mechanisms of dapagliflozin. This evidence concerns the gene AKT1 and type 2 diabetes mellitus.