Although no EC-derived exosomal circRNA has been characterized yet, a study by Li et al. in 2018 showed that pancreatic carcinoma cells could transfer the circRNA circ-IARS to HUVECs, thus increasing their permeability and promoting invasion and metastasis through a miR-122/RhoA axis [98]. Here, RHOA is linked to exocrine pancreatic carcinoma.