APOH and autoimmune polyendocrinopathy: However according to the re-evaluated risk profile of the obstetric APS, low APLA titers confer risk for pregnancy morbidity in addition to the widely accepted risk associated with medium/high APLA titers; persistent double positivity for LA and low titers of anti-β2GPI IgG display a higher risk than low aCL and anti-β2GPI IgG, either alone or associated [11].