While many myeloid neoplasms with a genetic background develop at younger ages than those without a known genetic background, myeloid neoplasms with DDX41 variants are characterized by a late disease onset (mean age, 65 years) [22,23], which may hinder the identification of this gene as one of the genes responsible for genetic predisposition for myeloid leukemogenesis. The gene discussed is DDX41; the disease is myeloid neoplasm.