DDX41 and neoplasm: In addition, the disease with a DDX41 variant is characterized by male dominancy, fewer proliferating tumor cells, hypoplastic bone marrow, and unique co-existing gene mutational patterns as compared to those in other myeloid neoplasms [65,66], with only DDX41 variants being identified in many cases [61], suggesting a unique disease pathogenesis of myeloid neoplasms with DDX41 variants.