It was observed that among patients with IL-1 positive composite genotype, patients with peri-implantitis had a higher mean volume of PICF (healthy 0.51 μL vs. peri-implantitis 0.66 μL, p = 0.042) and higher mean concentrations of IL-1β (healthy 15.31 pg/μL vs. peri-implantitis 23.65 pg/μL, p = 0.612) and PGE2 (healthy 119.06 pg/μL vs. peri-implantitis 186.54 pg/μL, p = 0.043) than healthy patients. Here, IL1A is linked to Peri-Implantitis.