The main hypothesis of the study was that, in both healthy individuals and patients with peri-implantitis, an altered genotype of IL-1A, IL-1B, or IL-1RN would result in higher levels of pro-inflammatory mediators compared to patients without the altered genotype, and that this effect would be particularly pronounced in the peri-implantitis group. This evidence concerns the gene IL1A and Peri-Implantitis.