In addition, by performing RNA sequencing in kidneys isolated from DKD patients, Hu and colleagues reported that the novel lncRNA ENST00000436340 was upregulated in DKD and contributed to cytoskeleton rearrangement with collapsed AFs, upregulation of desmin, and downregulation of ZO-1, ultimately leading to podocyte injury and DKD [108]. This evidence concerns the gene DES and diabetic kidney disease.