Both human lung spheroids cell-derived ACE2-EVs and plasma-derived ACE2-EVs from patients with COVID-19 delivered via inhalation therapy promote viral clearance and reduce lung injury in cynomolgus macaques and hACE-2 transgenic mice challenged with authentic SARS-CoV-2, suggesting a potential function for EVs in the SARS-CoV-2 infection control mechanism [36,152]. Here, ACE2 is linked to infection.