MMP12 and metabolic disease: ME activity was lowest in the AA group with respect to the DC group only in Phase I. This fact added to the subsequent rise in the final phase of TP may be due to the disease’s effect on oxidative stress, inducing metabolic disorders, as has been described in previous studies in liver injury, in which the authors concluded that ME enzyme did not participate in the regenerative processes of the tissue and therefore did not need to increase its expression levels for greater recovery [39].