Although the exact pathogenesis of ILD in RA remains unclear [75,76,77,78], smoking, male gender, older age, high titers of ACPA, disease duration, and positivity of the Human leukocyte antigen (HLA)-DR4 were probable risk factors for RA-ILD [78,79,80,81,82]. This evidence concerns the gene PRTN3 and interstitial lung disease.