Shin et al. demonstrated that human umbilical cord blood-MSCs (hUCB-MSCs) could downregulate the activation of the NLRP3 inflammasome via a paracrine loop of IL-1β signaling in the CIA murine model [160], suggesting the therapeutic potential of hUCB-MSCs in RA treatment. Here, NLRP3 is linked to rheumatoid arthritis.