OCRL and oculocerebrorenal syndrome: To be exploited for light-induced PIP2 depletion, the segment of CRY2 which senses light and consequently undergoes a conformational change, fostering its association with the N-terminal region of CIB1 (CIBN), has been linked to the inositol 5′-phosphatase domain of OCRL (oculocerebrorenal syndrome of Lowe).