HOTAIR expression is regulated by the transcription factor FOXC1, and it interacts with miR-1, miR-145, miR-122, and RNA-binding motif protein 38 (RBM38) in HepG2, Bel-7402 and Huh7 cells, all contributing to HCC [110,111,112,113]. The gene discussed is HOTAIR; the disease is hepatocellular carcinoma.