In HCC cells, such as Bel-7402, Hep3B, HepG2, HuH-7, MHCC97, and SMMC-7721, MALAT1 sponges miR-195 causing the activation of EGFR, PI3K/AKT, and JAK/STAT signaling; miR143-3p upregulating ZEB1; miR-146-5p upregulating TNF receptor-associated factor 6 (TRAF6) resulting in activation of AKT; miR-22 increasing snail family transcription factor SNAIL; and miR-30a-5p upregulating vimentin, all of which contribute to augmentation of cell proliferation, invasion, and EMT [118,119,120,121,122]. Here, TRAF6 is linked to hepatocellular carcinoma.