A major complication of HCC is portal vein tumor thrombus (PVTT), and it was shown that lncRNA ICR (ICAM-1-related) was expressed in Intercellular adhesion molecule 1 (ICAM-1)-positive cancer stem cells (CSCs) regulating CSC function and leading to PVTT development [174]. The gene discussed is ICAM1; the disease is hepatocellular carcinoma.