HOTTIP (HOXA Transcript at the Distal Tip) is a 7.9 kb lncRNA located in chromosome 7p15 that is frequently upregulated in HCC tissues and cell lines, and its overexpression is correlated with aggressive clinicopathological features, including advanced tumor stages and poorer prognosis for HCC patients [36,95]. The gene discussed is HOTTIP; the disease is neoplasm.