lncRNA ZFAS1 (ZNFX1 antisense RNA1) levels correlated with intra- and extrahepatic HCC metastasis and poor prognosis, and it promoted HCC progression by squelching miRNA-150 with resultant upregulation of ZEB1 and matrix metalloproteinases MMP14 and MMP16 [170]. This evidence concerns the gene MMP16 and hepatocellular carcinoma.