TNFRSF11B and hepatocellular carcinoma: A potential role of H19 in promoting bone metastasis of HCC has been documented, in which H19 interacted with protein phosphatase 1 catalytic subunit alpha (PPP1CA), which dephosphorylated p38 MAPK with subsequent downregulation of osteoclastogenesis inhibitory factor osteoprotegerin (OPG) [141].