The overexpression of lncRNA-PRAL induced apoptosis in HCCLM3 and SMMC-7721 HCC cells but not in Hep3B (p53-deficient) and HuH-7 (p53-mutant) cells, indicating that the tumor suppressor function of lncRNA-PRAL is mediated by p53 [192]. Here, TP53 is linked to neoplasm.