Furthermore, in accordance with the previous observation, Cui and co-workers observed in the MPTP-induced PD mouse model that the inhibition of LRRK2 by Ado-Cbl resulted in restoring autophagy and, in turn, removed protein aggregations which could possibly aid the treatment of PD; in particular, they employed a Tetrahedral framework nucleic acid-VitB12 complex (TVC), which was aimed at overcoming possible limitations due to the blood–brain barrier and TC availability, obtaining good results on disease symptoms [137]. This evidence concerns the gene LRRK2 and Parkinson disease.