In fact, pharmacological inhibition of PARP by olaparib in HEY and A2780 ovarian cancer cells (which carry wild-type BRCA1/2 [76]) significantly downregulated the expression of SLC7A11 and GPX4 and increased p53 expression, which promoted ferroptosis and DNA damage and led to cell apoptosis. This evidence concerns the gene TP53 and ovarian cancer.