In addition, RGS2 and RGS4 interaction with PAR4 inhibits PAR4-related increase in expression of prooncogenic CRC-connected factors, including cyclooxygenase-2 (COX-2), activating transcription factor 3 (ATF3), basic transcription factor 3 (BTF3), SNAIL, zinc finger protein 91 (ZFP91) and Leishmania Heme Response 1 (LHR1) [71]. Here, PTGS2 is linked to colorectal carcinoma.