APC and colorectal carcinoma: Since AXIN’s RGS domain is responsible for binding APC protein, the main role of AXIN, which links it to CRC, is its involvement in β-catenin destruction complex within which it cooperates with already mentioned APC, glycogen synthase kinase3 (GSK3), casein kinase1 (CK1), and the E3 ubiquitin ligase component TrCP1 [24].