MAP1LC3B and neoplasm: These results may be attributed to the active participation of LC3B and SQSTM1/p62 in the process of autophagy, given their roles as essential structural components of the autophagosome [32], and recent literature also revealed that SQSTM1/p62 overexpression is capable of promoting mitochondrial and classical macroautophagy [33], which promote tumor progression and chemo-resistance.