In grade 3 gliomas, a significant, strong, positive correlation was observed between PI3K and mTOR, ULK2, UVRAG; mTOR and PTEN; PTEN and m-TOR, ULK 2, UVRAG; mTOR and PI3K, PTEN; ULK1 and ULK2, UVRAG; ULK 2 and PI3K, PTEN, ULK 1, UVRAG, VPS34; UVRAG and PI3K, PTEN, ULK1, ULK2, VPS34. This evidence concerns the gene PTEN and central nervous system cancer.