Under unfavorable hypoxic conditions, molecules such as hypoxia-induced factors (HIF2a and HIF2b), BECN1 (Beclin-1), and BNIP3 (BCL2/adenovirus E1B 19KDa interacting protein 2) serve as survival mechanisms, promoting the progression of GBM and its resistance to anticancer treatmentin vivo [12,13,14,15]. Here, BNIP3 is linked to glioblastoma.