JAK2 and neoplasm: Exosomes derived from bone marrow MSCs containing lymphocyte cytosolic protein 1 (LCP1) have been shown to foster OS proliferation, epithelial-mesenchymal transition (EMT) process, and metastasis through neuregulin receptor degradation protein-1 (Nrdp1) degradation and activation of the JAK2/STAT3 pathway, while its expression is negatively regulated by a tumor-suppressing miRNA miR-135a-5p [44].