DIRAS3 and Friedreich ataxia: Simultaneously, downregulation of DIRAS3 expression has not been previously observed in benign thyroid lesions, such as nodular goitres (NG) or follicular adenoma (FA) [30,31], and our detailed comparisons of DIRAS3 expression level revealed a significant decrease not only in benign lesions (compared to malignant ones), but also in NG compared to PTC.