TNF and pulmonary fibrosis: In vivo, as demonstrated by Periera Simon et al., who compared the effects exerted by MSCs on mice with bleomycin (BLM)-induced lung fibrosis according to their source, all types of MSCs were able to reduce the Aschroft score after 10 days of treatment; further, all MSCs, except placental ones, decreased hydroxyproline and αv-integrin and TNF-α mRNA levels.