Several studies have demonstrated that the protective role of these cells in sepsis can be mainly attributed to paracrine factors released by ASCs or other cells they interact with, such as interleukin-10 (IL-10) [14], prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-α)-stimulated gene/protein 6 or IL-6, among others [8]. This evidence concerns the gene TNF and Sepsis.