In fact, in addition to a number of SNPs within IGF-1 gene that have been reported in myopia [44], many recent genetic studies indicated that rs12423791 or rs6214 polymorphisms in IGF-1 were identified to be pivotally associated with high myopia in populations of Caucasian and Chinese people [45,46] but not in Japanese population [47,48]. This evidence concerns the gene IGF1 and myopia.