Further analysis using an insulin microarray resulted that the levels of insulin and those related factors including IGF2, IGF-2R, IGF binding protein 1 (IGFBP-1), IGFBP-2, IGFBP-3, IGFBP-4 and IGFBP-6 were markedly increased in patients with pathogenic myopia as compared with the controls [59]. Here, IGFBP4 is linked to myopia.