As depicted in Figure 1C, the forest plot displayed that GLIS1 could significantly affect the OS of GBMLGG (lower grade glioma and glioblastoma, p = 0.001), LGG (p = 0.003), SKCM (p = 0.003), SARC (sarcoma, p = 0.021), THCA (p = 0.043), and PRAD (p = 0.017) patients (Figure 2C). This evidence concerns the gene GLIS1 and central nervous system cancer.