A work conducted by Rong et al. demonstrated that GLIS1 accelerates the process of CD8+ T cell exhaustion in hepatocellular carcinoma by modulating the SGK1-STAT3-PD1 pathway, and exerts a synergistic effect with anti-PD1, providing a prospective method for cancer immunotherapy [23]. This evidence concerns the gene STAT3 and hepatocellular carcinoma.