Similarly, in pancreatic cancer cells, long non-coding RNA (lncRNA) PVT-1 and HOTAIR regulates YKT6 and VAMP3 [370] and SNAP23 with VAMP3 colocalization [371], respectively, thereby playing a role in the fusion of MVBs with the plasma membrane. This evidence concerns the gene VAMP3 and familial pancreatic carcinoma.