ANO6 and Scott syndrome: The relationship between membrane phospholipid bilayer scrambling and EV formation in human Scott syndrome was found to be due to a gene defect encoding the transmembrane protein 16F (TMEM16F), an occult Ca2+-activated phospholipid scramblase (CaPLSase) that passively transports phospholipids down their chemical gradients and mediates blood coagulation [110].