HMA mediated restoration of Caspase-3/GSDME significantly increases Ven-induced pyroptosisVenetoclax triggers pyroptosis in AML cells by cleaving GSDME, which is downregulated due to promoter methylation in AML cells and is associated with poor prognosis. GSDME overexpression, achieved through gene demethylation or HMA treatment, enhances Venetoclax-induced pyroptosis in AML. This evidence concerns the gene GSDME and acute myeloid leukemia.