BCL-2 family proteins in 5-Aza sensitizationRNAi-mediated knockdown of BCL-xL sensitizes AML cells to 5-Aza, with BCL-xL and MCL-1 playing a crucial role in sensitization. Navitoclax (combined inhibitor of BCL-2, Bcl-xL and Bcl-w) was reportedly more potent than Ven (a selective BCL2 inhibitor) in enhancing 5-Aza activity, highlighting the significance of targeting BCL-xL, BCL-w, and BCL2. The gene discussed is MCL1; the disease is acute myeloid leukemia.