BCL-2 family proteins in 5-Aza sensitizationRNAi-mediated knockdown of BCL-xL sensitizes AML cells to 5-Aza, with BCL-xL and MCL-1 playing a crucial role in sensitization. Navitoclax (combined inhibitor of BCL-2, Bcl-xL and Bcl-w) was reportedly more potent than Ven (a selective BCL2 inhibitor) in enhancing 5-Aza activity, highlighting the significance of targeting BCL-xL, BCL-w, and BCL2. This evidence concerns the gene BCL2L1 and acute myeloid leukemia.