TNF and obesity due to melanocortin 4 receptor deficiency: We have shown the convergence of diverse critically and physiologically important molecules like oxidized LDL (implicated in atherosclerosis/obesity), epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) (implicated in cancer), and tumor necrosis factor-α (TNF-α) (implicated in inflammation) via activating β-1,4-GalT-V [9].