Therefore, we investigated whether TGF-β regulates the increased expression of TSG-6 in ASCs using a combination of pro-inflammatory cocktails (IFN-γ, LPS, TNF-α, and IL-1β) in vitro and examined whether inhibition of TGF-β signaling alters the survival rate in an animal model of sepsis in vivo. This evidence concerns the gene TNFAIP6 and Sepsis.