NUMA1 and urinary bladder carcinoma: In this sense, it is exciting to recognize that the meta-analysis by van Rhijn et al. reported one of the first extensive literature reviews for the use of 18 markers and concluded that MSA, ImmunoCyt, NMP22, CYFRA21-1, LewisX, and FISH are the most promising markers for the surveillance [67,69,70,71] and early detection of bladder cancer.