The most commonly altered genes in tumor tissues were BRCA1-associated protein 1 (BAP1) (23%), AT-rich interaction domain 1A (ARID1A) (22%), fibroblast growth factor receptor 2 (FGFR2) (22%), isocitrate dehydrogenase isozyme 1 (IDH1) (22%), cyclin-dependent kinase inhibitor 2A (CDKN2A) (15%), CDKN2B (14%), phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) (14%), TP53 (11%), ataxia-telangiectasia mutated (ATM) (9%), IDH2 (9%), v-raf murine sarcoma viral oncogene homolog B1 (BRAF) (7%), SMARCA4 (7%), and FGFR3 (5%). The gene discussed is BAP1; the disease is neoplasm.