Boerner et al. [91] found, in a bi-institutional study with 412 patients with ICC, that IDH1 was the most common oncogenetic alteration and that TP53, KRAS, and CDKN2A alterations were independent prognostic factors in iCCA when controlling for clinical and pathologic variables, disease stage, and treatment. The gene discussed is CDKN2A; the disease is intrahepatic cholangiocarcinoma.