Proteins in cancer cell extracts that were co-immunoprecipitated with AGT included the proliferating cell nuclear antigen (PCNA) clamp that serves as a platform for replication proteins on DNA and the MCM2 (minichromosome maintenance complex 2) component of the replicative helicase as well as the ORC1 origin recognition complex [107] (Figure 10). This evidence concerns the gene PCNA and cancer.