IGHE and asthma: In asthma, alteration in metabolome due to disordered metabolic pathways (oxidation–reduction imbalance, disturbances of energy, lipid, and/or amino acid metabolisms) may mirror the changes associated with airway inflammation, airway obstruction, and mucus production [16] that may correlate with standard diagnostic parameters (functional lung tests, IgE levels, FeNO, etc.)[28].