By contrast, in another T-ALL model involving murine T cell progenitor cells transformed in vitro and then grown as allografts in recipient mice, the subsequent knockout of Prkaa1 led to reduced recovery of T-ALL cells and enhanced survival of the mice, suggesting that AMPK-α1 was acting as a tumour promoter [22]. The gene discussed is PRKAA1; the disease is acute lymphoblastic leukemia.