AKT1 and neoplasm: Furthermore, cucurbitacin D exerted suppressive effects on cervical cancer by inhibiting phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) and the signal transducer and activator of transcription 3 (STAT3) signaling cascade and enhancing the expressions of tumor-suppressing genes such as miR-145, miRNA-143, and miRNA34a [7].