TUBB and hydrops fetalis: Hence, the association between melatonin treatment and the extent of fibrosis present in HF was shown in rats with isoproterenol-induced HF, in which the treatment with melatonin for 28 days resulted in a decreased level of oxidative stress, insoluble and total collagen, and the partial prevention of the beta-tubulin alteration in the LV, with the final results being a reduction in mortality and a prolonged average survival time [58].