By the same token, Yuan Liu et al. demonstrated melatonin’s cardioprotective effect in HFpEF by attenuating obesity-induced myocardial oxidative stress and apoptosis and promoting the secretion of C1q/tumor necrosis factor-related protein 3 (CTRP3) by adipose tissue, thus ameliorating diastolic dysfunction in obesity-induced HFpEF [55]. This evidence concerns the gene C1QTNF3 and obesity due to melanocortin 4 receptor deficiency.