In liver cancer cells, the inhibitory or blocking effect of OCT has been shown on invasion and metastasis through the upregulation of phosphatidylethanolamine-binding protein 1; matrix metalloproteinases; and their tissue inhibitors, metalloproteinase-2 and E-cadherin and suppression of matrix metalloproteinase-2 [410]. Here, PLXNA2 is linked to liver cancer.