To block angiogenesis-mediated tumour growth and metastasis, several natural angiogenic inhibitors, including thrombospondin; interferon; matrix metalloproteinase inhibitors; synthetic angiogenesis inhibitors such as protease inhibitors; anti-adhesive peptides; and pharmacologic inhibitors, including AGM 1470/TNP 470; and thalidomide, have been reported in addition to tumour derived inhibitor angiostatin and endostatin. The gene discussed is COL18A1; the disease is neoplasm.