SST and acromegaly: The role of SSTR2 and SSTR5 heterodimerizations with enhanced response in acromegaly is further supported with observation describing the weak response of SST ligand in acromegaly with low SSTR2/SSTR5 ratio, as well as in the presence of the Sst5TMD4-truncated isoform of SSTR5 [350,351,352].