These hormones and types of the cells include corticotropic adenomas, which secrete adrenocorticotropic hormone (ACTH) (Cushing’s disease); somatotrophic adenomas secrete growth hormone (acromegaly); thyrotrophic adenomas secrete thyroid-stimulating hormone (TSH); gonadotropic adenomas secrete luteinizing hormone (LH) and follicle-stimulating hormone (FSH); and prolactinomas secrete prolactin (PRL). This evidence concerns the gene POMC and familial isolated pituitary adenoma.