In tumour aggressive growth and proliferation, the contribution of angiogenesis is enormous, and promoting factors include VEGF, bFGF, angiogenin, granulocyte colony-stimulating factor (GCSF), EGF hepatocyte growth factor, platelet-derived growth factor (PDGF) and cytokines [61,62,63]. The gene discussed is EGF; the disease is neoplasm.