In our cohort, the median of CSF-CXCL13 from primary and secondary B-cell lymphoma (826.3 pg/mL) and cerebral cryptococcosis (1843.5 pg/mL) were well above the determined cut-off for neuroborreliosis of 428.92 pg/mL. Here, CXCL13 is linked to B-cell non-Hodgkin lymphoma.