The highest CSF-CXCL13 levels were found in neuroborreliosis (median 3920 pg/mL; range: 142–23,055 pg/mL), cryptococcosis with CNS-involvement (median 1843.5 pg/mL; range: 66–45,609 pg/mL), and B-cell lymphoma (primary or secondary CNS-involvement; median 826.3 pg/mL; range: 7.8–4500 pg/mL). Here, CXCL13 is linked to cryptococcosis.