In previous studies, ROC curve analyses have been performed to determine a cut-off for the differential diagnostic accuracy of CSF-CXCL13 in neuroborreliosis with a wide range of 18.9–1726 pg/mL [8,9,10,13,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38]. This evidence concerns the gene CXCL13 and Lyme disease.