ATM and brain cancer: There are several ATM inhibitors that are undergoing Phase I clinical trials for locally advanced tumors: M4076 (NCT04882917), XRD-0394 (NCT05002140), AZD0156 (NCT02588105), or for brain cancer in combination with radiation therapy: AZD1390 (NCT03423628) and WSD0628 (NCT04917145); only one ATM inhibitor has progressed to Phase II trial, ART0380 (NCT05798611) [23].