We noted that the metastatic hepatoblastoma cell line, HLM_2, had higher levels of mRNA abundance of stemness markers Oct4, Nanog, Nestin, and Sox2 compared to the parent cell line, HuH6 [9], so we sought to explore the effects of PIM kinase inhibition on metastatic hepatoblastoma stemness. The gene discussed is SOX2; the disease is hepatoblastoma.