CNVs in sporadic pancreatic cancer. CNV analysis in PDAC has revealed common cancer CNVs, including amplifications of KRAS (12p12.1), GATA6 (18q11.2), MYC (8q24.2), ERBB2 (17q12), PAK4 (19q13), NCOA3/AIB1 (20q13.12), SKAP2/SCAP2 (7p15.2), and AKT2 (19q13), as well as deletions of SMAD4 (18q21.2), CDKN2A (9p21.3), CDKN2B (9p21.3), PTEN (10q23.31), MAP2K4 (17p12), RUNX3 (1p36.11), TP53 (17p13.1), DCC (18q21.1), and ARID1A (1p36.11) [74,75,76]. The gene discussed is TP53; the disease is cancer.