In a case–control cohort consisting of 1031 controls and 1027 pancreatic cancer cases, researchers demonstrated that CNVR2966.1, a CNV located in a gene desert region on 6q13, is significantly associated with the risk of developing disease and functions as a potential trans-acting regulator of the CDKN2B (p15 or INK4B) gene located on 9p21.3. The gene discussed is CDKN2B; the disease is familial pancreatic carcinoma.