Whereas the autoimmunity of cbp60b mutant could be fully rescued by EDS1 or PAD4 loss-of-function mutations, the autoimmunity resulting from CBP60b overexpression could not be rescued by the loss function of EDS1 or PAD4, suggesting that the autoimmunity displayed in knock-out and in overexpressing plants results from two different signaling pathways [11]. The gene discussed is PADI4; the disease is Autoimmunity.