MAP3K1 and Autoimmunity: Increasing evidence suggests that either the loss of function or overexpression of a defense-related gene, such as MEKK1 [21,22], MPK6 [23], Senescence-Associated E3 Ubiquitin Ligase 1 (SAUL1) [24,25,26], and CBP60b [11,12], leads to autoimmunity.