Here, we used a CS + LPS-induced COPD mouse model and a cellular model exposed to CSE to explore the antioxidant effects of Lut, attempting to connect the crosstalk between the TRPV1/SIRT6 and CYP2A13/NRF2 systems in cigarette smoke-induced COPD. This evidence concerns the gene TRPV1 and chronic obstructive pulmonary disease.