LRRK2 and Parkinson disease: Various Parkinson-causing mutations, including point mutations of the SNCA (e.g., A53T and E46K), LRRK2 (e.g., G2019S and R1441C), and GBA1 (e.g., N370S and L444P), induce destabilization of the αSyn tetrameric structure; this leads to an increase in monomeric forms, potentiates inclusion formation, and induces neurotoxicity [54,55,56].