PKHD1L1 and rectum adenocarcinoma: The PKHD1L1 mRNA expression was significantly downregulated in multiple cancers, including adrenocortical carcinoma (ACC), breast invasive carcinoma (BRCA), cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), esophageal carcinoma (ESCA), LUAD, lung squamous cell carcinoma (LUSC), rectum adenocarcinoma (READ), SKCM, and thyroid carcinoma (THCA), compared with normal tissues (Figure 1A).