Notably, our study reveals that PRV-ΔTK/ΔgE or PRV-∆TK-(CD2v)-∆gE-(p54) does not impede T cell proliferation in vivo, suggesting that the double knockout of TK and gE genes effectively eliminates T cell depletion induced by PRV-Fa infection. This evidence concerns the gene TKT and Friedreich ataxia.