CD8+ T-cells from SHP-1 deficient motheaten mice [119] showed more stable and longer-lasting immunological synapses with antigen-presenting cells (APC), which reduced the T-cell activation threshold, thereby increasing the activation of T cells with low antigen specificity, leading to effective tumor suppression through tumor-specific effector T cells [120,121]. This evidence concerns the gene NR0B2 and neoplasm.