The IL6/JAK2/STAT3 signaling axis is best studied in the context of tumor metastasis and tumor pathology since it induces epithelial–mesenchymal transition (EMT), resulting in tumor metastasis by promoting the expression of EMT-inducing transcription factors, such as Snail, ZEB1, JunB, and Twist1 [51,61,62,63,64]. The gene discussed is TWIST1; the disease is neoplasm.