In ovarian cancer, where SHP-1 expression levels are high, inhibiting SHP-1 expression gradually reduces tumor growth by increasing the intracellular levels of Cdk2/p27 Kip1 and Cdk2/SHP-1 complex [85], which is opposite to the mechanism used by SHP-1 to inhibit cell division. This evidence concerns the gene PTPN6 and ovarian carcinoma.