PCSK9 is a protease, mainly synthesized in the hepatocytes, that regulates the metabolism of the low-density lipoprotein receptor (LDLR) [5], leading to increased circulating levels of low-density lipoprotein cholesterol (LDL-C) strongly associated with the incidence of atherosclerotic CV disease (ASCVD) [6]. This evidence concerns the gene LDLR and atherosclerosis.