RANBP2 and amyotrophic lateral sclerosis: Interestingly, it has been observed that the loss of RanBP2 in mouse motoneurons results in multiple physiological disturbances including profound disruption of Cxcl14/Cxcl12-Cxcr4-Stat3-mediated chemokine signaling, which causes an amyotrophic lateral sclerosis (ALS)-like syndromes with hindlimb paralysis, respiratory distress and premature death [73].