Alterations in apoptosis-associated transcription factors, such as heat shock transcription factor 1 (HSF1) [30,31], gene expression modifications [32,33,34], and regulation of anti/pro-apoptotic proteins, such as the anti-apoptotic Bcl-2 protein and the p53 tumor suppressor protein [35,36], have been identified as physiological changes in cancer cells. The gene discussed is HSF1; the disease is cancer.