Although TGF-β1 has not been shown to exert an epigenetic gene control mechanism in asthmatic airway remodeling, TGF-β1 causes EMT by inducing the expression of DNA methyltransferases (DNMTs) such as DNMT1, DNMT3A, and DNMT3B in upper airway remodeling caused by chronic rhinosinusitis, indicating that TGF-β1 exerts an epigenetic gene control mechanism. Here, TGFB1 is linked to chronic rhinosinusitis.